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Literature summary extracted from

  • Hermes, M.; Geisler, H.; Osswald, H.; Riehle, R.; Kloor, D.
    Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation (2008), Biochem. Pharmacol., 75, 2100-2111.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 Hep-G2 cell
-
 Homo sapiens
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2.1.1.63 LN-18 cell
-
 Homo sapiens
-
2.1.1.63 LN-229 cell
-
 Homo sapiens
-
2.1.1.63 Tu-113 cell
-
 Homo sapiens
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2.1.1.63 Tu-132 cell
-
 Homo sapiens
-
2.1.1.63 U-87MG cell
-
 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
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 Homo sapiens
2.1.1.63 O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.63 Homo sapiens neither short-term (24 h) nor long-term changes (7 weeks) in S-adenosyl-L-methionine/S-adenosylhomocysteine ratio alter global or MGMT promoter methylation, however, experimentally elevated S-adenosylhomocysteine levels significantly decrease MGMT mRNA levels by more than 50% down